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Genetics Problem Spaces
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Behavioral Genetics Intro
Exercise Student Projects |
Behavioral
Genetics Literature Annotated Bibliography Benzaldehyde Paper Nuttley WM, Harbinder S, van der Kooy D (2001) Regulation of Distinct Attractive and Aversive Mechanisms Mediating Benzaldehyde Chemotaxis in Caenorhabditis elegans. Learning and Memory 8:170-181. Nuttley et al. is the classic
paper describing the complex chemotaxis response of Caenorhabditis to 100% benzaldehyde. In their assay, the nematode
moves toward the benzaldehyde for the first 20 min, but after that time
point, moves away from the benzaldehyde.
Their hypothesis is that 100% benzaldehyde triggers both an attractive
response and an aversive response. In
naïve worms, the attractive response overpowers the weak aversive response
and the worms move toward the benzaldehyde.
However after 20 min of exposure to 100% benzaldehyde, the response to
the attractive signal is reduced because of “habituation”. This leaves only the aversive response,
resulting in worms moving away from the benzaldehyde. Their evidence suggests that the 100%
benzaldehyde strengthens the aversive response although they don’t suggest a
mechanism by which the aversive response might be strengthened.
Reviews Rankin CH (2004) Invertebrate Learning: What can’t a worm learn? Curr Biol 14:R617-R618 [L-29] A very short review that summarizes recent findings about learning in Caenorhabditis including analysis of mutants. It also includes a short glossary of psychological terms used to describe different types of learning. Hobert O (2003) Behavioral Plasticity in C. elegans: Paradigms, Circuits, Genes. J Neurobiol 54:203-223. Mori I (1999) Genetics of Chemotaxis and Thermotaxis in the Nematode Caenorhabditis elegans. Ann Rev Genet 33:399-422. Chemotaxis Mutants Bargman CI, Harwieg E, Horvitz HR (1993) Odorant-Selective Genes and Neurons Mediate Olfaction in C. elegans. Cell 74:515-527. Classic paper characterizing olfactation (sense of smell) in
nematodes. Characterizes the different
volatile compounds that trigger chemotaxis in worms and analyzes the ability
of nematodes to distinguish among different scents. Identify genes (odr
genes) necessary to chemotaxis to these compounds. Identifies the neurons responsible for
detecting these scents. Learning Saeki S, Yomamoto M, Iino Y. (2001) Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans. J. Exp Biol 204:1757-1764. Learning Mutants Bernhard N, van der Kooy D (2000) A behavioral and genetic dissection of two forms of olfactory plasticity in C. elegans: adaptation and habituation. Learn Mem 7:199-212. Wen JYM, Kumar N, Morrison G. Rambaldini G. Runciman S. Rousseau J, van de Kooy D. (1997) Mutations that prevent associative learning in C. elegans. Behav Neurosci 111: 354-368. Gomez M, De Castro E, Guarin E, Sasakura H, Kuhara A, Mori I, Bartfai T, Bargmann CI, Nef P. (2001) Ca signaling via neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron 30:241-248. Saeki S, Yomamoto M, Iino Y. (2001) Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans. J. Exp Biol 204:1757-1764. Morrison GE, van der Kooy D (2001) A mutation in the AMPA-type glutamate receptor, glr-1, blocks olfactory associative and nonassociative learning in Caenorhabditis elegans. Behav Neurosci 115:640-649. Morrison GE, Wen JY, Runciman S, van der Kooy D (1999) Olfactory associative learning in Caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants. Behav Neurosci 113:358-367. Physiology of
Learning Colbert HA, Bargmann CI (1997) Environmental signals modulate olfactory acuity, discrimination and memory in Caenorhabditis elegans. Learn Mem 4:179-191. Nuttley WM, Atkinson-Leadbeater KP, van der Kooy D (2002) Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans. PNAS 99:12449-12454. Memory Beck CD, Rankin CH (1995) Heat shock disrupts long-term memory consolidation in Caenorhabditis elegans. Learn Mem 2:161-177. Morrison GE, vander Kooy D. (1997) Cold shock before associative conditioning blocks memory retrieval, but cold shock after conditioning blocks memory retention in Caenorhabditis elegans. Behav Neurosci 111:564-578. Rose JK, Kaun KR, Rankin CH (2002) A new group training procedure for habituation demonstrates that presynaptic glutamate release contributes to long-term memory in C. elegans. Learn Mem 9:130-137. Integrating
Environmental Cues Ishihara T, Iino Y, Mohri A, Mori I, Gengyo-Ando K, Mitani S, Katsura I (2002) Hen-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell 109:639-649.
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