Links to Important
Websites
BIO100 Spring 2005
Forensic DNA sites
FBI CODIS (Combined DNA Index System) database site
http://www.fbi.gov/hq/lab/codis/index1.htm
The Biology Project DNA forensic problems
http://www.biology.arizona.edu/human_bio/problem_sets/DNA_forensics_1/DNA_forensics.html
Forensic mathematics of DNA matching
http://dna-view.com/profile.htm
Nice tutorial on DNA evidence
http://science.howstuffworks.com/dna-evidence.htm
DNA detective – great site for example cases
http://www.dnalc.org/resources/dnadetective.html
very complete paper “The Evaluation of Forensic DNA evidence”
http://www.nap.edu/readingroom/books/DNA/index.html#con
Short tandem repeat (STR) DNA internet database
http://www.cstl.nist.gov/biotech/strbase/
The Innocence Project
http://www.innocenceproject.org/
Biological terrorism
CDC (Center for Disease Control and Prevention)
Center for Civilian Biodefense
http://www.hopkins-biodefense.org/index.html
American Society for Microbiology
http://www.asmusa.org/pasrc/bioprep.htm
Morbidity and Mortality Weekly (see what is happening weekly with transmissible diseases… follow epidemics!)
Academic Info has a site on bioterrorism
http://www.academicinfo.net/terrorismbio.html
Working Group on Civilian Biodefense (how to handle a biological attack!) you have to go through a few links but eventually can learn about anthrax, tularemia, smallpox, botulism toxin and plague.
http://www.ama-assn.org/ama/pub/category/6232.html
Victorian Government links with background and information on most common bioterrorist weapons.
http://www.dhs.vic.gov.au/phd/bioterrorism/
Mad Cow disease and TSEs
US Food and Drug Administration info about mad cow disease
http://www.fda.gov/oc/opacom/hottopics/bse.html
All about Prions
http://www.microbe.org/news/prions.asp
BBC news report on CJD
http://news.bbc.co.uk/1/hi/special_report/1999/06/99/bse_inquiry/360343.stm
Laughing death in
http://whyfiles.org/012mad_cow/6.html
Mad cow- CJD – a variety of links of all kinds
http://www.rense.com/health/madcowdata.html
The official mad cow disease page
a general one-pager on prion proteins
http://science-education.nih.gov/nihHTML/ose/snapshots/multimedia/ritn/prions/prions1.html
Keeping mad cow disease out of the
http://www.fda.gov/fdac/features/2001/201_cow.html
Chronic wasting disease in NY
http://www.dec.state.ny.us/website/dfwmr/wildlife/deer/cwd.html
http://msnbc.msn.com/id/7349409/
http://www.cell.com/content/article/abstract?uid=PIIS0092867400802329
Good website with structure and prion protein links
http://www.cmpharm.ucsf.edu/~wallacea/nobel.html
Prion diseasese
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Prions.html
Alzheimer’s disease
Alzheimer’s association
Alzheimer’s disease education and referral center – film on Alzheimer’s progression
Alheimer’s disease international
NIH Medline plus Alzheimer’s page – Overviews – What is
Alzheimer Disease (
http://www.nlm.nih.gov/medlineplus/alzheimersdisease.html
Transcription/Translation/Gene expression
Genetic Code
http://psyche.uthct.edu/shaun/SBlack/geneticd.html
Transcription and translation (same one as replication)
http://www.johnkyrk.com/DNAtranscription.html
Really cool website showing transcription and translation in 3-D – from my alma mater!
http://vcell.ndsu.nodak.edu/animations/
Cancer Links
p53 tumor suppressor protein
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.107
http://www.infobiogen.fr/services/chromcancer/Genes/P53ID88.html
American Cancer Society
http://www.cancer.org/docroot/home/index.asp
Cancer figures 2004 – Adobe file with tons of information
Cancer Cell
http://www.cellsalive.com/cam1.htm
National Cancer Institute (NCI) of the National Institutes of Health (NIH) – lots of information on cancers and clinical trials
Breast cancer information http://imaginis.com/breasthealth/genetic_risks.asp , http://www.nlm.nih.gov/medlineplus/breastcancer.html , http://condor.bcm.tmc.edu/ermb/bcgd/bcgd.html , http://www.ncbi.nlm.nih.gov/disease/Breast-ovary.html
Genetic Disease Case study information
Cystic Fibrosis information http://www.cff.org/home/ , http://www.cysticfibrosis.com/ , http://www.nlm.nih.gov/medlineplus/cysticfibrosis.html , http://www.ccff.ca/
Muscular dystrophy information http://www.mdausa.org/ , http://www.parentprojectmd.org/news/latest/index.html , http://www.ncbi.nlm.nih.gov/disease/DMD.html http://www.nlm.nih.gov/medlineplus/musculardystrophy.html
Huntington’s Disease information http://www.hdsa.org/ , http://www.ninds.nih.gov/disorders/huntington/huntington.htm , http://www.hda.org.uk/ , http://www.nlm.nih.gov/medlineplus/huntingtonsdisease.html
Inheritance and Mendelian Genetics
Mendel’s experiments in animation and described (good for review of what we did in class!)
http://www.mendel-museum.org/eng/1online/experiment.htm
Mendelian Genetics: Principles of Segregation
http://www.accessexcellence.org/RC/VL/GG/mendel.html - simple explanation and diagrams
http://staff.jccc.net/pdecell/transgenetics/monohybrid1.html
Mendelian Genetics: Principle of Independent Assortment
http://staff.jccc.net/pdecell/transgenetics/independent.html
Recessive and Dominance inheritance
http://www.accessexcellence.org/RC/VL/GG/recessive.html
X-linked inheritance
http://www.accessexcellence.org/RC/VL/GG/x-linked.html - hemophilia example
Human single-gene disorders
http://www.wellcome.ac.uk/en/genome/genesandbody/hg06b006.html
DNA structure
Animated tutorial on DNA structure – requires Chime though, which I don’t have!
http://molvis.sdsc.edu/dna/index.htm
Great animation and description of DNA, replication,
transcription, translation – this is the one I used in class
http://www.johnkyrk.com/DNAanatomy.html
Very straight-forward tutorial on DNA structure
http://www.rothamsted.bbsrc.ac.uk/notebook/courses/guide/dnast.htm#Com
DOE (Department of Energy) genome page – include the page for the human genome project
Human Genome Project Primer – may be useful for answering some questions!
Powerpoint format Adobe acrobat (.pdf) format
Howard Hughes Medical Institute Blazing a Genetic Trail – great site about finding the cystic fibrosis gene and other information!
http://www.hhmi.org/genetictrail/
http://www.ncbi.nlm.nih.gov/projects/genome/guide/human/
The NCBI Genes and Disease site (see pg 26 in your book) – more student friendly way to find diseases that have been mapped to chromosomes
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.preface.91
Human Gene Map at the
http://www.ncbi.nlm.nih.gov/projects/genome/genemap99/
Weizmann Institute of Science – gene cards – another place you can look up a gene
http://bioinfo.weizmann.ac.il/cards/index.shtml
Stem Cells:
National Institutes of Health Stem Cell Research and Information – Federal government information on stem cells.
http://stemcells.nih.gov/info/basics/StemCellBasics.pdf
http://www.ninds.nih.gov/funding/research/stem_cell/
http://stemcells.nih.gov/info/scireport/ pdf report on stem cells
http://www.georgetown.edu/research/nrcbl/
Science News Presented by BIO: Biotechnology Industry Organization
Information about MANY topics that we cover in this course.
Stem Cell Research News – independent organization that reports on stem cell research.
http://www.stemcellresearchnews.com/
Your Genes, Your Choices: Exploring the Issues Raised by Genetic Research – Department of Energy site on a variety of ethical issues.
http://www.ornl.gov/sci/techresources/Human_Genome/publicat/genechoice/index.html
http://gslc.genetics.utah.edu/units/stemcells/
Gene therapy – SCID example
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/G/GeneTherapy.html
Molecular Medicine in Action website – pretty advanced animations of various processes – including using viruses in gene therapy
http://www.iupui.edu/%7Ewellsctr/MMIA/htm/animations.htm
Clinical trials of all kinds of research – type in ‘stem cells’ and you will see a bunch of trials!
http://www.clinicaltrials.gov/
Stem Cell lines available for Federally funded research
http://stemcells.nih.gov/research/registry/eligibilityCriteria.asp
Cloning:
Human Genome Project cloning fact sheet
http://www.ornl.gov/sci/techresources/Human_Genome/elsi/cloning.shtml
A pro human cloning website – pretty interesting
Another human cloning website that is not as biased!
http://www.globalchange.com/clonlink.htm
Just like stem cell guy – this is has a lot of cloning facts and a cloning cartoon
http://gslc.genetics.utah.edu/units/cloning/
Therapeutic Cloning – information from the American Federation for Aging Research (also has some good links to other information)
http://www.infoaging.org/b-cloning-3-therapeutic.html
Scientific American article on how therapeutic cloning is done – nice pictures
http://www.sciam.com/article.cfm?articleID=00016CF7-CE54-1CF4-93F6809EC5880000