MIME-Version: 1.0 Content-Location: file:///C:/287B5513/BIO100termsTSEs.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stem Cells

Transmissible Spongiform E= ncephalopathies  BIO100 Principles of Biology   &nbs= p;       Spring 2005

 

1.&n= bsp;     Define the following words or phrases (give examples where appropriate):

 

Chronic Wasting disease

 

Creutzfeldt-Jacob disease.

 

Fatal Familial Insomnia

 

Gerstmann-Staussler-Scheinker Syndrome

 

Kuru

 

Mad Cow Disease

 

New-variant CJD

 

Prnp gene

 

Rendering

 

Scrapie

 

Transmissible Spongiform Encephal= opathies (TSEs)

 

2.&n= bsp;     What are the common pathological features of TSEs?

 

3.&n= bsp;     Describe the progression of a general TSE disease.<= /p>

 

4.&n= bsp;     Explain the differences between sporadic, familial,= and iatrogenic forms of CJD.

 

5.&n= bsp;     Why did mostly women and children contract kuru in the Fore tribe in Papua New Guinea?  What seemed to slow and stop the d= isease in this tribe?

 

6.&n= bsp;     What are the four major features of the protein-onl= y Prion Hypothesis?

 

7.&n= bsp;     What evidence supports the protein-only Prion Hypothesis?

 

8.&n= bsp;     Is Bovine Spongiform Encephalopathy related to nvCJD?  = Explain.

 

9.&n= bsp;     In what tissues are prion proteins found (in humans or other animals)?

 

10.&= nbsp; How are abnormal prion proteins inactivated/“= killed”?

 

11.&= nbsp; Based on reading the section on TSE infectivity through blood transfusions (pg. 1= 6), do you think all the strict blood controls are necessary?

 

12.&= nbsp; What other organisms besides humans have forms of TSEs? 

 

13.&= nbsp; What three hypotheses have been suggested for the sudden appearance of BSE in British cattle?