Douglas P. Easton
Department of Biology
State University College at Buffalo
1300 Elmwood Ave.
Buffalo, NY 14222
Ph.D. - 1972 The University of Iowa, Iowa City, Iowa
Major professors: Michael Solursh, Zoology; Roger Chalkley, Biochemistry.
BA - 1966 Cornell College, Mt. Vernon, Iowa; Major: Biology
2000-Present Professor of Biology, Buffalo State College
2000-Present Adjunct Professor of Molecular Biophysics, Roswell Park Cancer Institute
1983- 2000. Associate Professor of Biology, State University College at Buffalo.
1977-1983 Assistant Professor of Biology, State University College at Buffalo
1976-1977 Acting Assistant Professor of Zoology, University of Washington, Seattle Washington.
1974-1976 N.I.H. Postdoctoral Fellow, University of Washington. With Prof. Arthur H. Whiteley
1974 Acting Assistant Professor of Zoology, University of Washington.
1973-1974 Research Associate to Prof. Helen R. Whiteley, Department of Microbiology,
University of Washington School of Medicine.
1972-1973 N.I.H. Postdoctoral Trainee in Developmental Biology With Professor Arthur H.
Department of Zoology Univ. Washington
1969-1972 N.I.H Predoctoral Fellow, Department of Zoology, the
University of Iowa, Iowa City
1968-1969 N.S.F. Predoctoral Trainee, Dept. of Zoology, The University of Iowa.
1968-1970 Teaching Assistant, Department of Zoology, The University of Iowa.
1966-1968 Teaching Assistant, Department of Biology, Drake University, Des Moines, Iowa.
My research interests and the research in my laboratory center about the role of
chaperones in the stress responses of eukaryotic organisms. The work currently centers on
the expression of heat-shock proteins in and the structure-function relationships of the heat
shock proteins. The project I have been working on deals with determining the structural and
functional properties of the large hsp 70-like molecular chaperones, hsp110 and grp170.
My particular interest has been in modeling the structure of these molecules and in determining
their phylogenetic relationships. Recently I have been investigating the role of hsp110 and grp170
in the development of Drosophila and C. elegans.
Relevant Research Publications:
Easton, D.P., P.S. Rutledge and J.R. Spotila. 1987 Heat shock protein induction and
thermal tolerance are independent in adult salamanders. J. Exptl. Zool. 241:263.
Rutledge, P.S., D.P. Easton and J.R. Spotila. 1988. Heat shock proteins of the lungless
Eurycea bislineata and Desmognathus ochrophaeus. Comp.Biochem. Physiol. 88B:13-18
Rutledge, P.S., Spotila, J.R. and D.P. Easton. 1988. Heat hardening in response to two
of heat shock in the lungless salamanders Eurycea bislineata and Desmognathus ocrophaeus.
J. Therm. Biol. 12:235
Spotila, J.R., Standora, E.A., Easton, D.P. and P.S. Rutledge (1988) Bioenergetics,
resource partitioning in stressed habitats: Biophysical and molecular approaches. Physiol. Zool. 62:253-285
Near, J.C., Easton, D.P. Rutledge, P.S., Dickinson, D.P. and J.R. Spotila (1990)
Heat shock protein
gene expression in intact salamanders (Eurycea bislineata) in response to calibrated heat shocks and
high temperatures encountered in the field. J. Exptl Zool. 256:303
Lee-Yoon D., Easton, D., Murawski, M. Burd, R, and J.R. Subjeck (1995)
Identification of a major
subfamily of large hsp70-like proteins through the cloning of the mammalian 110-kDa heat shock protein.
J. Biol. Chem. 270 15725-15733.
Chen, X., Easton, D., Oh, H.-J., Lee-Yoon, D., Liu, X., and J. Subjeck (1996) The 170
regulated stress protein is a large HSP70-, HSP110-like protein of the endoplasmic reticulum.
FEBS Letters 380:68-72
Oh, Hyun Ju, Easton, D. , Murawski, M., Kaneko, Y. and J. Subjeck (1999)The Chaperoning
Activity of Hsp 110: Identification of Functional Domains by Use of Targeted Deletions. J Biol.
Chem. 274:22 15712-15718
Park, J, Easton, D.P, Chen, X, MacDonald, I.J. Wang, X-Y, and Subjeck, J.R. (2003) The
Properties of Grp170, A member of the Third Family of Hsp70 Related Proteins. Biochemistry 42: 14893-14903
Douglas P. Easton, Yoshiyuki Kaneko and John R. Subjeck (2000). The Hsp110
and Grp170 Stress Proteins:
Newly Reccognized Relatives of the Hsp70s. Cell Stress and Chaperones 5:276-290
John G. Facciponte, Xiang-Yang Wang, Ian J. MacDonald, Jun-eui Park,Hilal Arnouk,
Melissa J. Grimm,
Ying Li,Hyung Kim, Masoud H. Manjili, Douglas P. Easton, John R. Subjeck.(2005) Heat shock proteins
hsp70 and grp96: Structural insights Cancer Immunology and Immunotherapy (manuscript in the press)
Short Review Articles:
Easton, D. and Subjeck, J. (1997) The Large Hsp70-Like Moleclar Chaperones: Overview.
in, M.J Gething, ed.
Guidebook to Molecular Chaperones and Protein Folding Enzymes, Oxford University Press. pp.73-76
Easton, D. and Subjeck, J. (1997) Hsp 110. in M.J Gething, ed. Guidebook to Molecular
Protein Folding Enzymes, Oxford University Press. pp. 81-82
Easton, D. and Subjeck, J. (1997) GRP 170. in M.J, ed. Gething Guidebook to Molecular
and Protein Folding Enzymes, Oxford University Press 85-86
Presentations at Meetings:
Easton D.P., J.C. Near, P.S. Rutledge, D.P Dickinson and J.R. Spotila 1988 Induction
and Accumulation of
Hsp70 mRNA in adult salamanders in response to different heat stresses, including naturally occurring
thermal stress in the field. J. Cell. Biochem. (Suppl.) 12D:289 (Abst. 17th Annu. UCLA Symp. Mol. Cell Biol.)
Easton, Douglas P., Paul S. Rutledge, Joseph C. Near, Douglas P. Dickinson, and Scott
D. Paschke. (1990)
Heat Shock Protein 70 and Hsp 70 m-RNA induction in intact adult salamanders. (abst.) International
Institute of Biophysics and Genetics meetings on Heat Shock (Ravello, Italy)
Yoon, D., D. Easton, M. Murawski, X. Chen, R. Burd and J. Subjeck, The Cloning of Large
70-Like Proteins. Abstract, Papers presented at 1994 meeting on The Biology of Heat Shock
Proteins and Molecular Chaperones; Cold Spring Harbor Laboratories; p. 319
Easton D., H. Oh., X. Chen, M. Murawski, and J. Subjeck, The Large Hsp 70's. Abstract,
Papers presented at 1996 meeting on Molecular Chaperones and the Heat Shock Response;
Cold Spring Harbor Laboratories; p. 80
Easton, Douglas P. and John Subjeck, The Hsp 110 sub-family: Structural and
with hsp 70. Abstract, Papers presented at 1998 meeting on Molecular Chaperones and the Heat Shock
Response; Cold Spring Harbor Laboratories; p. 69
Oh, Hyun Ju, Xing Chen, Douglas Easton and John Subjeck, Hsp 110 Protects Heat
Denatured Protein and
Confers Cellular Thermaloresistance. Abstract, Papers presented at 1998 meeting on Molecular Chaperones
and the Heat Shock Response; Cold Spring Harbor Laboratories; p 194
Douglas P. Easton, Hyun Ju Oh, A. Latif Kazim, Xing Chen, Suparna Dutta and John
Subjeck The Hsp110 and
Grp170 Stress Proteins: Large Relatives Of The Hsp70 Family. Presented at Cold Spring Harbor Meeting on,
Molecular Chaperones and the Heat Shock Response. May 3-7(2000).